All pubs are open for bids and will continue trading as normal.
But if it is sold, the branch will most likely be branded with a new name, menu and prices.
The pub said: “It is a commercial decision taken by the company taken after long consideration.”
It hasn’t said if any potential buyers are lined up or why the 14 pubs were chosen.
Among the Wetherpoons set to close is The Queen’s Hotel in Newport city centre and Dee Hotel in Merseyside.
However, business will be usual for the pub until a buyer is found.
Wetherspoons spokesman Eddie Gershon said: “We can confirm that The Queen’s Hotel in Newport has been put up for sale.
“We totally understand that our loyal customers and staff will be disappointed with this decision.
“However, Wetherspoons does on occasion put some of its pubs up for sale.
“It is a commercial decision taken by the company taken after long consideration.
“The pub will continue to trade as normal until a buyer is found.”
Eddie added: “We have told our staff that if the pub is sold and they do not transfer to the purchaser, then we would look to redeploy our employees at other Wetherspoons pubs in the region.”
It’s not the first time Spoons has put the pub, which was originally opened in 1863, on the market.
The venue, which acts as a pub during the day and a late-opening bar with music on the evenings, was up for sale in 2017.
Now it’s going on the market with two companies.
More than 11,000 pubs have closed in the UK, according to the latest data from the Office for National Statistics.
Here is a list of the 14 pubs which could be affected:
- Chapel an Gansblydhen, Bodmin, Cornwall
- Brun Lea, Burnley, Lancashire
- Vulcan, Coatbridge, North Lanarkshire
- Time Piece, Dewsbury, West Yorkshire
- Bourtree, Hawick, Scottish Borders
- Last Plantagenet, Leicester, East Midlands
- Queens Hotel, Newport, Wales
- The Cross Keys, Peebles, Scottish Borders
- St George’s Hall, Redfield, Bristol
- Pennsylvanian, Rickmansworth, Hertfordshire
- Rhinoceros, Rotherham, South Yorkshire
- Butler’s Bell, Stafford, Staffordshire
- Friar Penketh, Warrington, Cheshire
- Dee Hotel, West Kirkby, Merseyside
- Alexander Bain, Wick, Caithness
UPDATE: The Chapel an Gansblydhen, in Bodmin, Cornwall, was originally included on this list, but Wetherspoons has since clarified that this bar is no longer up for sale and will be remaining open.